#### Introduction Monkeypox is a viral zoonotic disease that has recently garnered significant attention due to its outbreaks in various parts of the world. Though it has been known to science since the 1950s, the disease had remained relatively obscure until recent years, when increasing numbers of human cases began to surface. This article provides an overview of monkeypox, including its origins, symptoms, transmission, prevention, and the public health response. #### Origins and History Monkeypox was first identified in 1958 in laboratory monkeys, hence its name, though its natural reservoir is believed to be rodents and other small mammals. The first human case was recorded in 1970 in the Democratic Republic of the Congo (DRC), and since then, it has been primarily confined to Central and West African countries. However, sporadic cases have been reported outside Africa, often linked to travel or imported animals. #### Transmission Monkeypox is transmitted to humans through di...